Vaccine and Immunology

Current Research & Future Challenges

The extremely complex escape strategies of diseases for which vaccines are currently unavailable make vaccine development difficult. Novel vaccine design has seen both successes and failures in recent years, and the value of iterative techniques is becoming more widely recognized. In order to expedite the creation of vaccines, these combine the preclinical identification of novel antigens, adjuvants, and vectors with computer analysis of clinical data. Novel antigen candidates have been identified by structural and reverse vaccinology, and the development of promising adjuvants has been facilitated by molecular immunology. The foundation for bio-signatures that will serve as guidance for future vaccine design has been established by the gene expression patterns and immunological parameters in patients, vaccinations, and healthy controls.